| FETTERMAN | |----------------------------------MONOAMINES-------------------------------------------------------------| |
| NEUROTRANSMITTER |
Acetylcholine |
|
Dopamine |
Serotonin |
|
| Synthesis
Deactivation |
Acetate
+ choline
AChE then (choline uptake) |
Tyrosine
®
L-DOPA
®
DA
®
NE
MAOa (Enzyme in terminal buttons) MAOb Reuptake |
Tryptophan
®
5-HT MAOa
Reuptake |
glutamate
®
GABA
Reuptake |
|
| Location
Receptors |
ANS
ganglia
& skeletal muscles (N )
cortex, limbic system parasymp. targets (M) N = nicotinic receptors M = muscarinic receptors |
locus
coeruleus
to the
limbic system via the MFB alpha 1 & 2
|
substantia
nigra to the basal ganglia & the ventral tegmentum to the limbic
system
via the MFB
D1, 2, 3 & D4 receptors |
Raphe
nucleus
to the limbic system via the MFB
Hypothalamus 5-HT a & b |
whole
brain,
limbic system esp. amygdala GABA 1 &2 |
| Function | learning, REM sleep | arousal,
wakefulness,
mood |
reward, mood, movement | sleep,
wakefulness,
mood, feeding |
reduce
anxiety,
increase relaxation |
| SYNTHESIS
& storage |
CHOLINE | *RESERPINE
¯
(vesicles don’t store transmitter so MAO in button destroys
it)
*MAO Inhib *L-DOPA *L=DOPA * MAO Inhib *MAO Inhib |
|||
| RELEASE | BOTULINUM
TOXIN ¯
BLACK WIDOW VENOM |
*AMPHETAMINE | *AMPHETAMINE | ||
| ACTIVATE
RECEPTORS |
*NICOTINE
(E)
*MUSCARINE (I) |
*LSD | *ALCOHOL
*BARBITURATES
*BENZODIAZAPINE |
||
| BLOCK
RECEPTORS |
*CURARE
(N) ¯
*ATROPINE (M) ¯ |
*CHLORPROMAZINE¯
*HALOPERIDOL ¯ *CLOZAPINE ¯ |
|||
| DEACTIVATION | ORGANOPHOSPHATES
& NERVE GAS (Both deactivate AChE) |
*AMPHETAMINES
*COCAINE *TRICYCLIC ANTIDEPRESSANTS *LITHIUM ¯ (facil. reup) |
*AMPHETAMINES
*COCAINE |
*TRICYCLIC
ATIDEPRESSANTS
*SSRIs (PROZAC) |
|